Paclitaxel waa diterpenoid-ka laga soo saaro Taxus genus Taxus, saynisyahannadu waxay ogaadeen in ay leedahay firfircooni antitumor xoog leh oo ku saabsan tijaabooyinka baarista.Hadda,paclitaxelwaxaa si weyn loogu isticmaalaa daawaynta kansarka naasaha, kansarka ugxan-sidaha, kansarka sambabada unugyada aan yarayn, kansarka ganaca, kansarka hunguriga, kansarka caloosha, madaxa iyo qoorta, sarcoma jilicsan iyo burooyinka kale ee xun, waana mid ka mid ah kuwa ugu badan. loo isticmaalo daawoyinka kemotherabi marka lagu jiro waxqabadka kiliinikada.Haddaba sidee buu paclitaxel ula dagaallami karaa kansarka?Aan hoos eegno.
Sidee paclitaxel ula dagaallamaan kansarka?Sida la wada ogsoon yahay inta lagu guda jiro kala qaybinta unugyada caadiga ah, unuggu wuxuu u qaybsan yahay laba qaybood.Ka dib markii koromosoomka la soo koobo, fiilaha lafdhabarta ayaa ka soo jiidaya meesheedii hore ee labada dhinacba, iyo spindle-ku wuxuu u baahan yahay depolymerization ee microtubules sida cytoskeleton si uu u sameeyo, Chromosomes kaliya waxay dhamaystiri karaan mitosis iyagoo u guuraya tiirarka hoos yimaada xarigga lafdhabarta iyo xuubka dunta, sidaas darteed microtubules ayaa aad muhiim ugu ah qaybinta unugyada.
Sannadkii 1979 kii, Horwitz oo ku takhasusay dawooyinka ayaa taas ogaadaypaclitaxelwaxay ku xidhi kartaa tubulin waxayna kor u qaadi kartaa polymerization of tubulin si ay u sameyso microtubules, taas oo ka hortagaysa kala qaybsanaanta jireed ee caadiga ah ee microtubules, taas oo ka dhigaysa inay awoodi wayday inay sameyso dunta iyo fiilooyinka dunta, samaynta unugyada Awood la'aanta qaybinta si caadi ah waxay ka hortagtaa taranka degdega ah ee unugyada kansarka waxayna keentaa apoptosis unugyada kansarka.Sidaa darteed, ka mid ah dawooyinka ka hortagga kansarka, paclitaxel waxaa loo tixgeliyaa sida microtubule inhibitor ee mitosis.
Xusuusin: Waxtarka suurtagalka ah iyo codsiyada lagu sharraxay maqaalkan waxay ka soo jeedaan suugaanta la daabacay.
Akhriska la dheereeyey:Yunnan Hande Biotechnology Co., Ltd. waxa ay diiradda saareysay soo saarista paclitaxel muddo 28 sano ah.Waa saaraha ugu horreeya ee madax-bannaan ee adduunka ee daawada paclitaxel ee ka hortagga kansarka ee ay ansixisay US FDA, European EDQM, Australian TGA, China CFDA, India, Japan iyo hay'adaha kale ee sharciyeynta qaranka.ganacsi.Haddii aad rabto inaad iibsatoPaclitaxel API,fadlan online nagala soo xidhiidh.
Waqtiga post: Seb-30-2022