Habka wax soo saarka ee Paclitaxel, oo ah daawo si ballaaran loo isticmaalo daaweynta kansarka, waa nidaam adag oo casri ah oo daboolaya tillaabooyin badan, laga soo saaro ilaha dabiiciga ah ilaa habka ugu dambeeya ee dawooyinka.Warqadani waxay soo bandhigi doontaa habka wax soo saarka eepaclitaxel, laga bilaabo soo saarista ilaa diyaarinta.
Tallaabada 1: Soo saar
Paclitaxelwaxaa asal ahaan laga soo saaray jilif geedka Yew Pacific, Taxus pacifica.Nidaamku wuxuu ka bilaabmaa ururinta jilif waxayna badanaa u baahan tahay in si taxadar leh loo maareeyo si looga fogaado waxyeellada geedka.Maaddada jilif ee la ururiyey ayaa markaa la jejebiyaa waxaana la geliyaa dareere habboon, sida ether ama xylene.Paclitaxel ayaa laga soo milmaanaa jilifta una rogmataa dareere tallaabadan si loo sameeyo soosaar.
Talaabada 2: Kala saarida
Soosaarayaashu waxay inta badan ku jiraan xeryahooda kala duwan oo kala duwan, markaa paclitaxel waxay u baahan tahay in laga sooco xeryahooda kale.Talaabadani waxay badanaa isticmaashaa chromatography chromatography ama farsamooyinka kale ee kala soocida si loo kala saaro paclitaxel iyo walxaha kale ee ku salaysan sifooyinka xarunta.
Tallaabada 3: Nadiifinta
Paclitaxel-ka kala go'a wuxuu u baahan yahay in la sii sifeeyo si meesha looga saaro wasakhda hartay oo loo helo badeeco saafi ah.Tani waxay caadi ahaan ku lug leedahay tillaabooyinka sida crystallization, sifeynta, iyo recrystallization si loo hubiyo in paclitaxel-ka ugu dambeeya uu yahay nadiif sare.
Talaabada 4: Synthesis (ikhtiyaar)
Inkasta oo paclitaxel-kii asalka ahaa laga soo saaray ilo dabiici ah, dhowr shirkadood oo dawooyin ah ayaa soo saaray habab ay ku abuuraan.Hababkani waxay adeegsadaan dariiqyada kiimikaad ee synthetic si ay u kordhiyaan wax-soo-saarka iyo xakamaynta una yareeyaan ku-tiirsanaanta khayraadka dabiiciga ah.
Tallaabada 5: Diyaari daawada
Talaabada ugu dambeysa ee habka wax soo saarka waa diyaarinta paclitaxel la safeeyey oo loo diyaariyey isticmaalka caafimaadka.Tani waxay ku lug yeelan kartaa milanka paclitaxel ee dareeraha habboon, sida khamriga ama ether, si loogu diyaariyo diyaarinta dawooyinka.Foomka ugu caansan waxaa loo diyaariyaa sidii xal la isku duro si loo hubiyo qiyaasta saxda ah.
Isku soo wada duuboo, habka wax soo saarka eepaclitaxelwaa geedi socod adag oo dhowr tallaabo ah oo loogu talagalay in lagu hubiyo nadiifnimada sare iyo xakamaynta daawada ugu dambeysa.Guusha geeddi-socodkan ayaa muhiim u ah bixinta daawaynta kansarka oo wax ku ool ah, sidaas darteed si joogto ah ayaa loo wanaajiyaa oo loo hagaajiyaa si loo daboolo baahiyaha caafimaad.
Fiiro gaar ah: Faa'iidooyinka iyo codsiyada suurtagalka ah ee lagu soo bandhigay maqaalkan waxay ka soo jeedaan suugaanta la daabacay.
Yunnan Hande Biotechnology Co., Ltd. ayaa diiradda saarey wax soo saarka paclitaxel muddo 26 sano ah, waana soo saaraha madax-bannaan ee dhirta laga soo saaray daawada kansarka ka hortagga paclitaxel API oo ay ansixisay FDA United States, European EDQM, Australia TGA, China CFDA , Hindiya, Japan iyo hay'adaha kale ee sharci ee qaranka.Yunnan Hande paclitaxel, sahayda booska, iibka tooska ah ee warshadda, ku soo dhawoow inaad waydiiso, 18187887160 (WhatsApp isla lambarka)
Waqtiga boostada: Oct-13-2023