Paclitaxel waa badeeco dabiici ah oo asal ahaan laga soo saaray jilif geedka yew Pacific (Taxus pacifica) biosynthesis ee paclitaxel waxay ku lug leedahay wadooyin biosynthetic adag, oo ay ku jiraan enzymes badan iyo dhexdhexaadin. Halkan waxaa ah dulmar guud oo ku saabsan biosynthesis ee paclitaxel:
Maaddada bilawga ah: biosynthesis ee paclitaxel waxay ku bilaabataa walxo dabiici ah, oo inta badan laga soo bilaabo caleemaha ama jilif geedka yew. Qalabkan bilawga ah waxaa ku jira xeryahooda waalidka oo loo isticmaali karo in lagu soo saaro paclitaxel's precursors.
2.Multi-enzyme catalysis: Biosynthesis ofpaclitaxelWaxay u baahan tahay ensaymes badan si ay u kiciyaan falcelinta. Ensaymes-yadani waxay u beddelaan walaxda bilawga ah dhexdhexaad kuwaas oo si tartiib tartiib ah u soo saara unugyada hore ee paclitaxel.
3.Synthesis of intermediates: Dhexdhexaadiyayaashu waa tallaabo muhiim ah oo ka mid ah isku-darka paclitaxel. Waxay ka kooban yihiin xeryahooda polycyclic iyo qaababka silsiladaha dhinacyada kuwaas oo si tartiib tartiib ah u soo baxa iyada oo loo marayo taxane falcelin ah oo enzyme-catalyzed.
4.Final synthesis of paclitaxel:Molecules precursor for synthesis of paclitaxel ayaa si tartiib tartiib ah loogu soo daray molecules paclitaxel ee tallaabooyin falcelin badan.
5. Soo saarista iyo nadiifinta: Ka dib marka la isku daro paclitaxel, tallaabo saarista iyo nadiifinta ayaa loo baahan yahay si loo kala saaro paclitaxel saafi ah oo ka soo baxa falcelinta falcelinta.
Inkastoo dariiqooyinka biosynthetic dabiiciga ah eepaclitaxelLa darsay, wax soo saarka dhabta ah ee paclitaxel ayaa weli ah mid adag sababtoo ah waxay u baahan tahay isku-dhafan adag oo leh tillaabooyin badan iyo xaddi badan oo alaabta ceeriin ah. Caqabadahan awgeed, saynisyahannadu waxay sidoo kale baareen dariiqyada synthetic si ay u soo saaraan paclitaxel si ay u kordhiyaan wax-soo-saarka iyo helitaanka. Synthetic synthesis of paclitaxel sida caadiga ah waxay ku lug leedahay dariiqa habaynta oo la fududeeyay si loo yareeyo kakanaanta.
Fiiro gaar ah: Faa'iidooyinka iyo codsiyada suurtagalka ah ee lagu soo bandhigay maqaalkan waxay ka soo jeedaan suugaanta la daabacay.
Yunnan Hande Biotechnology Co., Ltd. waxa uu diiradda saaray wax soo saarka paclitaxel muddo 26 sano ah, waana saaraha madax-bannaan ee warshad-soosaaray anti-kansarka paclitaxel API ansixiyay United States FDA, Yurub EDQM, Australia TGA, Shiinaha CFDA ,Hindiya,Japan iyo hay'adaha kale ee sharciyaynta qaranka Yunnan Hande paclitaxel,goob keenida,warshada iibka tooska ah,ku soo dhawoow in aad waydiiso,18187887160(WhatsApp isla number)
Waqtiga boostada: Oct-12-2023