Paclitaxel, oo ah badeeco dabiici ah oo laga soo saaro fir cas, waxay joojisaa mitosis unugga burooyinka iyagoo ku dhaqmaya borotiinnada microtubule.Waa wakiilka caadiga ah ee fasalka paclitaxel waana daawada kiimikaad ee ugu horeysay ee ka soo jeeda dhirta dabiiciga ah si ay u hesho ogolaanshaha FDA ee daaweynta kansarrada kala duwan, oo ay ku jiraan ugxan-sidaha, naaska, sambabada, Kaposi's sarcoma, kansarka ilmo-galeenka iyo pancreatic.Sanadihii ugu dambeeyey,paclitaxelsidoo kale waxay caan ku noqotay isticmaalkeeda aaladaha caafimaadka.Aan ku eegno maqaalkan soo socda.
Isticmaalkapaclitaxelqalabka caafimaadka
Paclitaxel, iyada oo loo marayo polymerization isla mar ahaantaana leh α (α-tubulin) iyo β (β-tubulin) ee microtubulin, waxay sababtaa tiro badan oo ah microtubules si ay u polymerize si aan caadi ahayn, taasoo keentay isbeddelka dheellitirka lafaha unugyada unugyada iyo luminta shaqada caadiga ah. taasoo keenaysa horumarinta unuggu inay joojiyaan marxaladda G0 / G1 iyo G1 iyo GM, iyo unugyada mitosis si looga hortago marxaladda mitotic, ugu dambeyntii lagu gaaro xakameynta qaybta muruqyada siman ee xididdada, faafinta Natiijadu waa in la xakameeyo kala qaybinta iyo faafinta murqaha siman ee xididdada xididada. iyo ka hortagga restenosis inuu dhaco.
1. Paclitaxelstent daroogada
Daroog-eluting stent (DES) waa stent ah oo adeegsata madal stent bir ah oo qaawan si uu u qaado (qaado) daawada faafinta ka hortagga endothelial, kaas oo ay sii daayaan elution maxalliga ah ee markabka si ay si wax ku ool ah u joojiyaan faafitaanka endothelial si looga hortago restenosis stent.Isticmaalka wax ku oolka ah ee stent-ka-jiidashada maandooriyaha ayaa si weyn u yareeyay dhacdooyinka restenosis iyo dib-u-dhexgelinta, laakiin ma yareynin heerka cudurrada iyo dhimashada.Ma jirin farqi weyn oo u dhexeeya dhacdooyinka dhamaadka dhamaadka kiliinikada ee udhaxeeya stent-daroogo, iyada oo qaar ka mid ah dhibcaha ugu dambeeya ay ka faa'iideysanayaan.Xargaha dawadu ka baxdo waxaa ka mid ah stent qaawan oo ka samaysan bir aan bir lahayn ama kobalt-chromium kuwaas oo ay ku daboolan yihiin sidayaal dawooyinka lidka ku ah oo leh dahaarka gudbinta daawada polymeric oo ay ku jiraan tignoolajiyada dahaarka dawada joogta ah, noole-bidegradable, iyo polymer-free-polymer, oo ay ku jiraan dawooyin ay ku jiraan limoxylates iyo paclitaxel.Waqtigan xaadirka ah, stents daroogada paclitaxel ayaa inta badan loo isticmaalaa daaweynta cudurrada kala duwan ee wadnaha, intracranial, carotid, kelyaha iyo halbowlayaasha femoral.
2. Paclitaxel buufinnada dahaarka leh ee daroogada
Buufin-dahaarka maandooriyaha (DCB), oo ah farsamo faragelin cusub oo qaan-gaar ah, ayaa lagu caddeeyey dhowr tijaabo oo caafimaad oo waxtarkeeda iyo badbaadada ISR ah, nabarada stenosis intracoronary, nabarrada maraakiibta yaryar, nabarrada laba-laabashada, iwm.
Fiiro gaar ah: Waxtarka suurtagalka ah iyo codsiyada lagu sharraxay maqaalkan waxay ka soo jeedaan suugaanta la daabacay.
Akhriska la dheereeyey:Yunnan Hande Biotechnology Co., Ltd. waxa ay diiradda saareysay soo saarista paclitaxel muddo 28 sano ah.Waa saaraha ugu horreeya ee madax-bannaan ee adduunka ee daawada paclitaxel ee ka hortagga kansarka ee ay ansixisay US FDA, European EDQM, Australian TGA, China CFDA, India, Japan iyo hay'adaha kale ee sharciyeynta qaranka.ganacsi.Haddii aad rabto inaad iibsatoPaclitaxel API, fadlan nagala soo xidhiidh online.
Waqtiga boostada: Oct-09-2022