Paclitaxel waa daawo cusub oo ka hortagta microtubule, taas oo si weyn loogu isticmaalo daaweynta kiliinikada ee kansarka ugxansidaha, kansarka naasaha, kansarka sanbabada, burooyinka madaxa iyo qoorta, kansarka hunguriga, kansarka gastric iyo unugyada jilicsan ee sarcoma. Sanadihii la soo dhaafay, albumin bound taxol ayaa la soo saaray. iyada oo loo marayo sahaminta joogtada ah ee cashuuraha iyo hagaajinta joogtada ah ee tignoolajiyada diyaarinta. Aynu eegno sifooyinka paclitaxel-ku xidhan Albumin.
Albumin-ku-xidhan paclitaxel: nanoparticles ka samaysan paclitaxel iyo serum albumin aadanaha by tignoolajiyada gariirka cadaadiska sare, hal albumin molecule iyo toddoba paclitaxel molecules ayaa la isku daray, iyo doorka albumin receptor Gp60 ee xuubka gacanta iyo cysteine hodanka ah acidic albumen SPARC) ee nudaha burada waxaa loo isticmaalaa in kor loogu qaado daawada si loo galo unugyada burada oo loo kordhiyo saamaynta kemotherabi.
1. Amniga
Albumin-bound paclitaxel: Looma baahna saliidda qaboojiyaha ee polyoxyethyl castor, taas oo si badbaado leh u kordhin karta qiyaasta paclitaxel, soo gaabin karta wakhtiga faleebada, wax ka-hortag ahna looma baahna.
2. daawaynta
Albumin-ku xiran paclitaxel uma baahna daawayn ka hor si looga hortago falcelinta xasaasiyadda ka hor maamulka.
3. Falcelinta xun
Albumin-bound paclitaxel iyo paclitaxel liposomes: Iyadoo ay ugu wacan tahay hagaajinta tignoolajiyada diyaarinta, looma baahna in lagu daro waxyaabaha dheeraadka ah sida saliidda polyoxyethyl castor, polysorbate 80, ethanol absolute, iwm, iyo badbaadada daawada si weyn ayaa loo hagaajiyay.
4. Tilmaamaha
Albumin-bound paclitaxel: suugaanta laxiriirta ayaa ku warameysa in dawadeeda kaliya iyo habka isku-darka ah ay tahay ikhtiyaarka daawaynta kansarka naasaha ee horumarsan ee si degdeg ah u socda ama ku guuldareysta daawaynta safka badan. Markii hore lagu daweeyay paclitaxel, waxyeellooyinkeedana waa kuwo loo dulqaadan karo.
Fiiro gaar ah: Waxtarka suurtagalka ah iyo codsiyada lagu soo bandhigay maqaalkan dhamaantood waxay ka yimaadeen suugaanta la daabacay.
Yunnan Hande Biotechnology Co., Ltd ayaa ku takhasusay wax soo saarkapaclitaxel APIin ka badan 20 sano, oo waa mid ka mid ah saarayaasha madax-bannaan ee adduunka ee paclitaxel API, a warshad-ka soo jeeda daawada kansarka, ansixiyay US FDA, Yurub EDQM, Australian TGA, Chinese CFDA, India, Japan iyo hay'adaha kale ee sharci qaran. .Hande ma bixin karo oo keliya tayada sarealaabta ceeriin paclitaxel,laakin sidoo kale adeegyada cusboonaysiinta farsamada ee la xidhiidha qaabaynta paclitaxel. Wixii macluumaad dheeraad ah, fadlan xor u noqo inaad nagala soo xidhiidho 18187887160.
Waqtiga boostada: Dec-29-2022