Daawooyinka Paclitaxel ayaa loo tixgeliyey daaweynta safka koowaad ee kansarka naasaha, waxaana si weyn loogu isticmaalaa kiliinikada kansarka ugxan-sidaha, kansarka sanbabada, burooyinka madaxa iyo qoorta, kansarka hunguriga, kansarka caloosha iyo sarcoma jilicsan.Sanadihii la soo dhaafay, iyada oo loo marayo sahaminta joogtada ah ee daawooyinka paclitaxel iyo horumarinta joogtada ah ee habka diyaarinta, daawooyinkan hadda inta badan waxaa ka mid ah cirbadeynta paclitaxel, docetaxel (docetaxel), lipsomal paclitaxel iyo albumin-bound paclitaxel.Haddaba maxay ku kala duwan yihiin daawooyinkan paclitaxel, aynu hoos wax badan ka ogaanno.
I. Kala duwanaanshaha shaqooyinka aasaasiga ah
1. Paclitaxel cirbadeynta: Waxaa lagu tilmaamaa safka koowaad iyo dabagalka daaweynta kansarka ugxansidaha horusocod ah, daawaynta adjuvant ee kansarka naasaha qanjidhada togan ka dib nidaamka caadiga ah ee adriamycin-ka kooban chemotherapy, kansarka naasaha ee kansarka naasaha metastatic ku guul daraystay isku darka kemotherabi ama dib u soo noqoshada 6 bilood gudahood ee daaweynta kemotherabi ee adjuvant, daawaynta safka kowaad ee kansarka sambabada unugyada yaryar, iyo daawaynta safka labaad ee kansarka la xidhiidha bukaanka AIDS-ka.
2. Docetaxel: Loogu talagalay daawaynta kansarka naasaha ee horumaray ama metastatic ee ku dhacay kiimoterabi ka hor;loogu talagalay daawaynta kansarka sanbabada unug-yar oo horumarsan ama dheef-shiid kiimikaad ah oo ku guul darraystay daawaynta kiimikaad ku salaysan cisplatin.Waxay kaloo waxtar u leedahay kansarka caloosha iyo kansarka qanjirka 'prostate'.
3. Liposomal paclitaxel: Waxa loo isticmaali karaa daawaynta kowaad ee kiimiko ee kansarka ugxan-sidaha iyo daawaynta safka kowaad ee daaweynta kansarka ugxan-sidaha ugxan-sidaha, waxa kale oo loo isticmaali karaa iyadoo lagu daray cisplatin.Waxa kale oo loo isticmaali karaa daawaynta daba-galka ah ee bukaanka kansarka naasaha ee lagu daweeyey kiimoterabiga caadiga ah ee ay ku jirto adriamycin ama daawaynta bukaanka soo noqnoqda.Waxa kale oo lagu dari karaa cisplatin oo ah kiimoterabiga safka kowaad ee bukaanada qaba kansarka sambabada unugyada aan yarayn ee aan lagu daweyn karin qaliin ama shucaac.
4. Albumin-bound paclitaxel: loogu talagalay daawaynta kansarka naasaha ee metastatic kaas oo ku guuldareystay isku darka kemotherabi ama kansarka naasaha kaas oo soo noqnoqday 6 bilood gudahood ka dib daaweynta kemotherabi ee adjuvant.Ilaa ay jirto iska-hor-imaad bukaan-socod ah, kiimoteraabi hore waa in lagu daraa wakiilka ka hortagga kansarka ee anthracycline.
II.Kala duwanaanshaha badbaadada daroogada
1. Paclitaxel: milmayn biyaha oo liita.Guud ahaan, duritaanku wuxuu ku dari doonaa surfactants saliidda castor polyoxyethylene-la beddelay iyo ethanol si loo hagaajiyo milanka paclitaxel ee biyaha, laakiin histamine waa la sii daayaa marka saliidda castor ee polyoxyethylene lagu beddelo ay hoos u dhacdo gudaha vivo, taas oo horseedi karta fal-celin xasaasiyadeed oo daran waxayna sidoo kale ka sii dari kartaa neurotoxicity durugsan ee paclitaxel, iyo sidoo kale saamayn kartaa fidinta ee molecules daroogada ee unugyo iyo saamayn saamaynta anti-buro.
2. Docetaxel: milanka biyuhu wuu hooseeyaa, waxaana loo baahan yahay in lagu milmo iyadoo lagu darayo polysorbate 80 iyo ethanol anhydrous, labaduba waxay kordhin karaan dhacdooyinka falcelinta xun waxayna sababi karaan falcelinta xasaasiyadda iyo hemolytic.
3. Liposomal paclitaxel: dawadu waxay ku duuban tahay xayndaabyo u eg lipid si ay u sameeyaan unugyo yar-yar, daawaduna waxa ay ku xidhan tahay qaybo liposomal ah oo aan lahayn saliidda castor ee polyoxyethylene lagu beddelay iyo ethanol anhydrous, taas oo keenta dareen-celin xasaasiyadeed.Si kastaba ha ahaatee, daraasaduhu waxay muujiyeen in daawada paclitaxel lafteedu ay sidoo kale keeni karto dareen-celin xasaasiyadeed, laakiin heer hoose marka loo eego cirbadda paclitaxel.Waqtigan xaadirka ah, liposomes paclitaxel waxay wali u baahan yihiin daawaynta xasaasiyadda kahor intaan la isticmaalin.
4. Albumin-bound paclitaxel: Waa paclitaxel cusub oo albumin lyophilized ah oo isticmaalaya albumin biniaadmi ah sida xamaaliyaha daroogada iyo xasiliyaha, kaas oo aan ku jirin saliidda castor ee isku-darka ah ee polyoxyethylene-la beddelay oo leh wax yar oo paclitaxel ah oo leh paclitaxel liposomes, oo aan lahayn u baahan daawayn ka hor daawaynta ka hor.
Fiiro gaar ah: waxtarka suurtagalka ah iyo codsiyada lagu sheegay bandhiggan waxa laga soo qaatay suugaanta la daabacay.
Yunnan Hande Biotechnology Co., Ltd ayaa ku takhasusay wax soo saarkapaclitaxel APIin ka badan 20 sano, waana mid ka mid ah soosaarayaasha madax-bannaan ee adduunka ee paclitaxel API, oo ah daawada ka hortagga kansarka ee dhirta, oo ay ansixisay US FDA, European EDQM, Australian TGA, Chinese CFDA, India, Japan iyo hay'adaha kale ee sharci ee qaranka. .Hande waxay bixin kartaa ma aha oo kaliya tayada sarealaabta ceeriin paclitaxel, laakiin sidoo kale adeegyada cusboonaysiinta farsamada ee la xidhiidha samaynta paclitaxel.Wixii macluumaad dheeraad ah, fadlan xor u noqo inaad nagala soo xidhiidho 18187887160.
Waqtiga boostada: Dec-08-2022