Paclitaxel waa daawo dabiici ah oo heer sare ah oo ka hortagga kansarka oo la helay hadda. Waxaa si weyn loo isticmaalaa daaweynta kiliinikada ee kansarka ugxan-sidaha, kansarka naasaha, kansarka sanbabada, burooyinka madaxa iyo qoorta, kansarka hunguriga, kansarka caloosha iyo sarcoma jilicsan.Paclitaxelayaa soo jiidatay xiisaha weyn ee saynisyahano sababtoo ah qaabdhismeedka kiimikada ee kakan oo cusub, hababka nafleyda ee gaarka ah ee ficilka, waxqabadka kansarka la isku halleyn karo, iyo kheyraad yari ba'an. Sida laga soo xigtay tirakoobka, in ka badan 30 shaybaarrada ugu sarreeya adduunka ayaa ku hawlan cilmi-baarista Total synthesis of paclitaxel, tartankuna waa mid aad u adag, kaas oo noqday diiradda kiimiko synthetic organic dabayaaqadii qarnigii 20aad.
Habka gaarka ah ee ka hortagga burooyinka ee paclitaxel
Paclitaxel waxay ka dhigi kartaa Tubulin iyo Tubulin dimer kuwaas oo ka kooban microtubules luminaya dheellitirka firfircoonida, kicinta iyo kor u qaadista polymerization Tubulin, ururinta microtubule, iyo ka hortagga depolymerization, si ay u xasiliyaan microtubules oo ay u joojiyaan mitosis unugyada kansarka waxayna kiciyaan apoptosis, si wax ku ool ah looga hortago kororka kansarka. unugyo iyo ciyaarista doorka ka hortagga kansarka.
Dhab ahaantii, Tubulin, taas oo si dhow ula xiriirta Mitosis unug, ka jira ku dhawaad caalami ah ee dhammaan unugyada eukaryotic. Waxay polymerize karaa galay microtubules rogaal celis ah. Kala saarida chromosome waxay u baahan tahay caawinta kuwan microtubules. Mitosis ka dib, kuwan microtubules ayaa mar kale depolymerized galay Tubulin. Burburka dubbaha sida microtubules waxay doorbidayaan inay dilaan unugyada kala qaybsanaan aan caadi ahayn. Qaar ka mid ah dawooyinka ka hortagga kansarka ee muhiimka ah, sida colchicine, Vinblastine, Vincristine, waxay door ka ciyaaraan ka hortagga burooyinka iyagoo ka hortagaya Tubulin inay dib u soo celiso.
liddi ku ah mitosis iyo dawooyinka ka hortagga burooyinka,paclitaxelwaa daawada ugu horeysa ee la helo oo la falgeli karta Tubulin polymer, taas oo ah, waxay ka shaqeysaa iyadoo si dhow loo isku darayo microtubules si ay u xasilaan. Isla mar ahaantaana, waxaa la ogaaday in paclitaxel ay muujiso saameyn wanaagsan oo ku saabsan noocyo kala duwan oo unugyada burooyinka adag. daah-furka ayaa soo jiitay cilmi-baarayaal badan si ay u isticmaalaanpaclitaxelSida qalab cilmi baaris ah oo ku saabsan biomedicine, sahaminta qaybaha aan la garanayn ee dhaqdhaqaaqa unugyada iyo helitaanka hababka cusub ee daawooyinka kansarka.
Sharaxaad:Wax ku oolnimada suurtagalka ah iyo codsiyada lagu sheegay maqaalkan waxay dhammaantood ka soo jeedaan suugaanta si guud loo heli karo.
Yunnan Hande Bio-tech waxa ay diiradda saareysay soo saarista paclitaxel muddo 28 sano ah.Waa shirkad wax soo saar oo madax-banaan oo ah alaabta ceeriin ee paclitaxel, kaas oo ay ansixiyeen wakaaladaha sharciyeynta qaranka sida FDA ee Maraykanka, EDQM ee Europe, TGA ee Australia, CFDA ee Shiinaha, India, iyo Japan.Yunnan Handepaclitaxelwaxaa laga heli karaa stock oo ay si toos ah u iibiyaan saarayaasha.Ku soo dhawoow inaad wax weyddiiso.
Waqtiga boostada: Jun-12-2023